For these reasons, before you start taking diethylstilbestrol it is important that your doctor knows:. Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with diethylstilbestrol. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice. Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once.
Take the container with you, even if it is empty. If you buy any medicines, check with a pharmacist that they are suitable to take with your other medicines. This medicine is for you. Two of the most commonly used names were stilbestrol and DESPlex, but there are dozens more.
Write down and save anything you find out about dates the drug was taken, and other details. In many cases, it may not be possible to find out if DES was used. And there are no medical tests that can tell you if you were exposed to DES. Women who took DES appear to have an increased risk of breast cancer.
Of course, many other factors affect breast cancer risk as well. A woman who took DES while pregnant or suspects she may have been given it should tell her doctor. If possible, she should try to find out the dose, when the medicine was started, and how it was used. She also should tell her children who were exposed in the womb. They need to tell their doctors, so that this information can be included in their medical records.
DES-exposed mothers should follow a regular schedule for early breast cancer detection, as is recommended for all women. Women should report any new breast lumps or other breast changes to a doctor right away.
They should also have regular medical check-ups. This cancer of the vagina and cervix usually occurs in DES-exposed daughters in their late teens or early 20s. But it has been reported as early as age 8, and the upper age limit, if any, is not known. DES-exposed daughters are now older than 40, but their risk may still be higher than in women who were not exposed. Treatment for CCA depends on the location and stage extent of the cancer.
For more information on the treatment of clear cell adenocarcinoma, see Vaginal Cancer or Cervical Cancer. DES exposure before birth has been linked to a higher risk of having abnormal cells in the cervix and vagina. These abnormal cells look like cancer cells.
But they do not spread into nearby healthy tissues like cancer cells do and so are often called pre-cancers. DES-exposed daughters may have a vagina, uterus, or cervix with an unusual shape or form structure. But some can cause problems for women who want to get pregnant or cause other reproductive health problems.
At least part of this difference seems to be caused by changes in the shape of the uterus. DES-exposed daughters may also be more likely to have irregular menstrual periods, which could add to fertility problems. DES-exposed daughters may also have a higher risk of certain problems during pregnancy. Adolescents and Young Adults with Cancer. Emotional Support for Young People with Cancer. Cancers by Body Location.
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Prior Approvals. Annual Reporting and Auditing. Transfer of a Grant. Grant Closeout. Cancer Training at NCI. Resources for Trainees. This reduces testosterone levels and may help to control the cancer. Diethylstilbestrol comes as tablets you can take at home. You may have diethylstilbestrol on its own or with other drugs. Your nurse or doctor will talk to you about your treatment plan.
Always take the tablets exactly as explained. This is important to make sure they work as well as possible for you. Make sure you:. If you forget to take the tablets, you should take the missed dose as soon as possible within the same day. If a full day has passed, let your doctor or nurse know. Do not take a double dose unless your doctor tells you to. Your nurse or pharmacist may also give you other medicines to take home. Take all your medicines exactly as they have been explained to you.
Do not stop taking any of your medicines unless your doctor tells you to. We explain the most common side effects of this treatment here. We also include some less common side effects. You may get some of the side effects we mention, but you are unlikely to get all of them.
If you are also having treatment with other cancer drugs, you may have some side effects that we have not listed here. Always tell your doctor, nurse or pharmacist about any side effects you have. Your doctor can give you drugs to help control some side effects. It is important to take them exactly as your nurse or pharmacist explains. This means they will be more likely to work for you. Your nurse will give you advice about managing your side effects. After your treatment is over, most side effects start to improve.
Some cancer treatments can cause severe side effects. Rarely, these may be life-threatening. Your cancer doctor or nurse can explain the risk of these side effects to you. Your nurse will give you telephone numbers for the hospital. If you feel unwell or need advice, you can call them at any time of the day or night. Save these numbers in your phone or keep them somewhere safe.
Some people have an allergic reaction while having this treatment. Signs of a reaction can include:. If you feel unwell or have any of these signs, tell a doctor or nurse straight away. Do not take any more of this treatment until you have spoken to them. This treatment may cause swelling and tenderness of your breast tissue.
This is called gynaecomastia. Your doctor can give you advice on preventing and treating this. Most men lose their sex drive and have erection problems during hormonal therapy.
Things often return to normal after you stop taking the drug. But some men continue to have problems after treatment is over. Your doctor can prescribe treatments to help with erection problems.
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